Thursday, May 30th 2013

NVIDIA Tesla Powers HIV Research Breakthrough

Researchers at the University of Illinois at Urbana-Champaign (UIUC) have achieved a major breakthrough in the battle to fight the spread of the human immunodeficiency virus (HIV) using NVIDIA Tesla GPU accelerators, NVIDIA today announced.

Featured on the cover of the latest issue of Nature, the world's most-cited interdisciplinary science journal, a new paper details how UIUC researchers collaborating with researchers at the University of Pittsburgh School of Medicine have, for the first time, determined the precise chemical structure of the HIV "capsid," a protein shell that protects the virus's genetic material and is a key to its virulence. Understanding this structure may hold the key to the development of new and more effective antiretroviral drugs to combat a virus that has killed an estimated 25 million people and infected 34 million more.

UIUC researchers uncovered detail about the capsid structure by running the first all-atom simulation of HIV on the Blue Waters Supercomputer. Powered by 3,000 NVIDIA Tesla K20X GPU accelerators -- the highest performance, most efficient accelerators ever built -- the Cray XK7 supercomputer gave researchers the computational performance to run the largest simulation ever published, involving 64 million atoms.

"It would have been very difficult to run a simulation of this size without the power of GPU-accelerated supercomputing in the Blue Waters system," said Klaus Schulten, professor of physics at the University of Illinois. "We started using GPU accelerators more than five years ago, and GPUs have fundamentally accelerated the pace of our research."

Designed to accelerate a broad range of scientific and technical computing applications, NVIDIA Tesla GPU accelerators are enabling researchers worldwide to make dramatic new breakthroughs across a variety of scientific domains -- including alternative energy, astrophysics, drug development, and climate research, among others. They deliver significantly higher performance and better energy efficiency as compared with CPU-based systems.

"GPUs help researchers push the envelope of scientific discovery, enabling them to solve bigger problems and gain insight into larger and more complex systems," said Sumit Gupta, general manager of the Tesla Accelerated Computing Business Unit at NVIDIA. "Blue Waters and the Titan supercomputer, the world's No. 1 open science supercomputer at Oak Ridge National Labs, are just two of many GPU-equipped systems that are enabling the next wave of real-world scientific discovery."

Capsid May Be Key to More Effective Drugs
With the planned addition of more GPUs to the Blue Waters system, UIUC researchers expect to increase simulation times, providing additional insight into the structure and behavior of the HIV capsid.

The capsid has become an attractive target for the development of new antiretroviral drugs, largely due to the discovery that Rhesus monkeys have developed an immunity to HIV through a protein that disrupts capsid functioning.

The capsid is the protein cell of a virus, containing the virus's genetic material. It protects and "smuggles" the genetic material into the human host cell. Once inside, it uncoats the material and initiates the infection.

No existing HIV drug treatments are designed to target the capsid. However, by providing a better understanding of the structure of the HIV capsid, pharmacologists have a wealth of new information to develop new and potentially more effective antiviral HIV drugs.
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66 Comments on NVIDIA Tesla Powers HIV Research Breakthrough

#1
Death Star
by: Bytales
Just to point out something here.
Zero point energy is allready a viable source of energy.

The second this technology was announced publicly USA-goverment made it illegal to use such energy inside USA.

Why ? Because they cannot own it, as said techlogy was invented by an iranian. If you want to know more, just look up with google, Keshe Foundation, or click here http://www.keshefoundation.org/.
The funny thing is, the iranian who invented said technology is ready to give it up for free so that we all may freely benefit for it.
Hes not trying to make more money than god, as some pointed out. Or as some would do in his place !

We have allready invented the technology that makes interstellar travel a reality, we have the technology to discard petrol all togther, to have free energy for the rest of our lives, but why havent you people heard of it allready ?

Let me answer to that ! Because such knowledge is being systematically supressed, as is the case with urine therapy as well.

Another info is also that if you do the right things you can live in your biological body that you have now forever.
So please spare me the '' super computer X was used to find a treatment for the super diseases Y" discussion.

The good part of it all, is that such knowledge is starting to emerge, and more and more people will learn what the truth really is.
This is worse than religious radicalism.
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#2
W1zzard
by: Death Star
This is worse than religious radicalism.
it's exactly the same. big claims, big promises, believers, some nice backstory, good vs. evil, no real evidence
Posted on Reply
#3
tigger
I'm the only one
The majority of people with HIV are the ones that could not afford to pay for a cure, do you think if some company found a cure they would charge ten dollars for it so all these poor people with HIV could afford it........NOT A CHANCE, it would cost far more than most of the suffers could afford.
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#4
Prima.Vera
by: tigger
The majority of people with HIV are the ones that could not afford to pay for a cure, do you think if some company found a cure they would charge ten dollars for it so all these poor people with HIV could afford it........NOT A CHANCE, it would cost far more than most of the suffers could afford.
Only in 'merica. Only in 'merica... The country with the WORST medical insurance system in the world. :shadedshu
And don't get me starting with the UK...
Posted on Reply
#5
Vinska
I doubt the company would benefit much if no one can even afford their meds.
And unsold product is not a product that brings revenue.
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#6
tigger
I'm the only one
by: Prima.Vera
Only in 'merica. Only in 'merica... The country with the WORST medical insurance system in the world. :shadedshu
And don't get me starting with the UK...
Ours might not be the best but at least we have it.
Posted on Reply
#7
ste2425
by: Bytales

We have allready invented the technology that makes interstellar travel a reality, we have the technology to discard petrol all togther, to have free energy for the rest of our lives, but why havent you people heard of it allready ?
Don't know much about all this government corporate cover up stuff but i hope that much is wrong i ain't never giving up my motor for a dam electric or what ever alternative is available. I intend to own a Ford Capri and MK1 Escort and drive them regardless.
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#8
YogurtMaster
Meh, I would rather have a cure for diseases like Cancer. More people die of Cancer than that of HIV.
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#9
Fatal
Much love to anyone who folds sure it takes time and nothing is free really these days. There are a few that really care for others I am thankful there are. Breakthroughs have been made that’s great news any progress is better than none at all. The way people are worked these days don’t care what health care you have we are rocketing to an early grave.
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#10
tigger
I'm the only one
by: ste2425
Don't know much about all this government corporate cover up stuff but i hope that much is wrong i ain't never giving up my motor for a dam electric or what ever alternative is available. I intend to own a Ford Capri and MK1 Escort and drive them regardless.
That stuff is possibly right, there is no denying EVERY first world government has their fingers in some very dirty pies, that we will never know about, much of it to "protect" the population.
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#11
ste2425
by: tigger
That stuff is possibly right, there is no denying EVERY first world government has their fingers in some very dirty pies, that we will never know about, much of it to "protect" the population.
I agree to some extent there's government's that would be reluctant to disclose technologies such as a viable alternative to petrol. Not too sure what tax's are on fuel in other countries but over here they would loose a hell of allot of money. Things like saying governments created these supper diseases to control populations and don't want to give the cure sounds like people have watched too many movies.
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#12
Fourstaff
by: ste2425
I agree to some extent there's government's that would be reluctant to disclose technologies such as a viable alternative to petrol. Not too sure what tax's are on fuel in other countries but over here they would loose a hell of allot of money. Things like saying governments created these supper diseases to control populations and don't want to give the cure sounds like people have watched too many movies.
You know if there are actually viable alternatives to whatever technology, unless its extremely sensitive the private sector will have a whiff of the idea and capitalise it.
Posted on Reply
#13
ensabrenoir
by: arterius2
wrong

Food for thought: ever wonder what's actually keeping the population of lets say, majority of African nations in check, you got it, HIV. (well among with famine and other nasty things)

a slow and painless murder is called population control, otherwise, its just called murder.
......It seems that intelligence without conscience is really just another shade of ignorance...
Posted on Reply
#14
DannibusX
RAGE, RAGE, nVidia GPU's were used in a breakthrough in AIDS research! RAGE, RAGE.

AIDS is a population control mechanism RAGE, RAGE.

If the USGov really wanted to control the population, they'd open every door and window at the CDC.

Or they'd spray chemicals in the air.

Or they'd genetically modify the food supply.

Crazy bastards.
Posted on Reply
#15
Chevalr1c
Warning: Incoming rant

The average post at generalnonsense.net leaves a better impression than a majority of the posts here. Don't you folks realise that Tesla based supercomputers generally compute stuff way more energy efficient (AFAIK) than X86 based SCs? And I will pass on the matter of drinking piss curing , that is even too silly to reply to. And those "population control" guys better go let themselves get sterilised, for some proper "population control" of such pitiful louses in this world.

A proper TPUer does not act like a fool.
Posted on Reply
#16
johnspack
Been holding off, but... we fold and perhaps use energy, that we pay for, to try to help these causes. We use our expensive equipment gladly, and knowing it will die in the process. I'm poor, so it's really hard for me, but at least I know I am trying to do something about it, instead of shoving my thumb up my butt while playing video games! And that conspiracy stuff, man, really?
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