only 1 problem for me : tried to activate VSR on a screen who is not meant to be used with it
i had to safe mode boot and DDU the driver (safemode also in DDU options) but after that, smooth as butter and less instability in framerates in games (well in the games where i noticed a drop instead of a improvement.)
for the so called borking desktop : user fault at most, when i installed the drivers they prompted me, when i opened CCC, to change the DPI according to my resolution, well i ended with humongous icons.
easy to correct anyway, but if you never used that option previously you might end cursing the driver, afaik a pop up windows who ask you to change your DPI (if you are fine with your desktop : no reason to do so) require a user action, aka: press OK button ... but as i wrote a bit above, if you are fine with your current DPI then no need, so tick the "never show again" box and press cancel.
in practice : you go there.
but then i have a 290 i should try on my R7 240 to see if there is any difference (since my other ATI/AMD card is a 5450 and a 3650 and the 5xxx serie is not supported anymore in the new drivers if i am not mistaken )