Yeah, it can
hurt. If you're at the lowest stable notch in the BIOS and you're trying to fine-tweak it even lower, you're really
pushing yourself to the very edge of the cliff of stability, with a strong wind blowing...
Also, what if you happen to make a miscalculation while crunching or folding? What if you make the problem you were trying to solve worse
by sending in bad units? Sado say, measure twice, cut once.