OMG Quad's.... lol... Quads are soooo 2010.
This season is all about Hexacore processors. And OMG your ram must be all 1333 or 1600 which is just a geek faux pas.
And is that a GTX 460? Oh, were going to have to close the door on that one...
Ok, kidding aside your system is still bangin. Areas of improvement might be the gpu without going overboard. A nice new Hex-core cpu would require a new board(I'm assuming) and then you might want to upgrade the ram to 2000+Mhz 8GB kits. Your WC loop is still nice, probably need to give it a cleaning though.
Other than a thorough cleaning I'd say its still alive.