Originally Posted by KieX
Decided to follow the links on the new BOINC clients and found something pretty interesting. Not sure if anyone else has seen this. The FightAIDS@Home project published a PDF recently that basically gives an update on their research.
A 5-10 minute read more or less (depends how many things you want to wikipedia as you read along
) It's quite cool to actually see what results they're getting from our crunching efforts. If you fancy a read, the link is below:
FightAIDS@Home Project Update - Volume 10
(PDF Format - 1.83MB)
This part sounds dirty . . . . and a little scary.
The “eye site” is a little hole that opens
up when the flaps that guard the active
site are in a semi-open or fully open
state. The compounds with green and
magenta carbon atoms shown as sticks
in the image on the left are bound in the
eye site. The eye site is also called the
“flap recognition pocket,” because when
the flaps are closed, the tip of one flap
wedges into this region between the
other flap and the top of the wall of the
active site. If the “eye site” is gummed
up with an inhibitor, then the flaps cannot
close properly. These flaps must be able to open, close completely, and then re-open repeatedly
(like your jaw) in order for HIV protease to perform its chemical work: chopping the newlysynthesized
viral multi-protein polypeptide in several specific spots, which separates those viral
proteins into their individual units.