Personally I'd do a driver sweeper method of driver uninstallation and reinstallation.
Download the latest nvidia driver from the nvidia website.
Then I'd reinstall directx.
Is it a steam game and is something updating/downloading while you are in game?
Try disbling settings one at a time and seeing which it is hurting you most.
Set Nvidia control panel to "use application settings" and not "overriding" or "enhancing" anything.
Turn FXAA off in control panel as well and check.
Same with vsync and triple bufering "which should go off by default I think"
Oh yea.. Crysis 2 wasn't on steam.. Origin onry..
There is nothing more dangerous than sincere ignorance and conscientious stupidity. "Martin Luther King"