If you are worried about infection of the OS simply partition the OS and swap/temp files and another for your personal data.
Why would you unplug a drive? And to answer your question yes, RAID 5 will allow for continued operation while a drive is missing, or replaced and rebuilt.
I have had to do it once on a Highpoint controller, it took 18 hours to rebuild a 1TB array with three partitions, databases and backups. Performance was degraded by about 50% while the rebuild took place.
“it would have been perfect....its got trains and the line"tech your kids not to do what iv done"(or similar) because i had obviously done something to warrent 2 e-thugs to come 4000miles out of their way and kill me.” -Solaris17
“yeah i failed. i noticed the "coming soon" part after i posted.” -Mussels
Yes I am evil, yes you can have some.