I've had quite a headache trying to fold 24/7 on my 4870x2. Was getting plagued with errors. So here what found works best. First of is to replace amd dlls in the folding dir(assuming nvidia has a similar way). You can either install the drivers, or run the setup to extract the files you need. Once you have the drivers installed you can copy the files from your windows folder. Or navigate to where the driver install extracted and navigate to: 9-6_vista64_win7_64_dd_ccc_wdm_enu\Driver\Packages\Drivers\Display\W76A_INF\B_81503 In here you need 2 files aticalcl.dl_ & aticalrt.dl_ (you can use the 64bit versions too) Copy these to your folding dir, and open up a command prompt window here and type the following (make sure you've deleted the amd dlls first): expand aticalcl.dl_ aticalcl.dll del aticalcl.dl_ -y expand aticalrt.dl_ aticalrt.dll del aticalrt.dl_ -y ren aticalcl.dll amdcalcl.dll ren aticalrt.dll amdcalrt.dll Now here what makes it work, you have to use environment variables, which can be reached by going to your computer properties (Advanced System Properties) and goto the advanced tab, down at the bottom you'll see Environment Variables.... Add the following variables to System Variables: Variable=Value CAL_NO_FLUSH=1 BROOK_YIELD=2 FLUSH_INTERVAL=128 CAL_PRE_FLUSH=1 Then reboot your machine and Happy Folding. I here this helps for smp folding as well.