With the socket AM3+ platform, ASUS wants to rally around its top motherboard brands, including Republic of Gamers (ROG), with the ASUS Crosshair V Formula, and the The Ultimate Force (TUF) Sabertooth 990FX, for AMD's next top of the line 990FX chipset that is designed to run up to four discrete graphics cards. The 990FX Sabertooth keeps up with the color scheme of the other TUF-series members. It boasts of highly durable components. The AM3+ socket is powered by a 10-phase Digi+ VRM. It is wired to four DDR3 DIMM slots supporting dual-channel DDR3-1866 MHz memory, and connects to the 990FX chipset over a HyperTransport 3.1 link.

Expansion slots include four PCI-Express 2.0 x16 (configurable as x16/x4/x8/x8, x16/x4/x16/NC, depending on how they're populated); The electrical x4 slot is wired to the SB950 southbridge, and is placed there to hold PCI-Express SSDs. One each of PCI-E x1 and PCI make for the rest of the expansion. Storage connectivity includes six internal SATA 6 Gb/s ports supporting RAID, two internal SATA 3 Gb/s from a third-party controller, one power-eSATA/USB combo, and one normal eSATA on the rear panel.Other connectivity features include 8+2 channel HD audio driven by Realtek ALC892 with optical SPDIF output, one gigabit Ethernet connection, four USB 3.0 ports (two rear, two by header), a number of USB 2.0 ports, and Firewire. The 990FX supports a number of ASUS-exclusive features including UEFI BIOS with EZMode, MemOK, Ceram!x heatsinks, etc.