Users have recently been reporting various intermittent USB connectivity errors on AMD 500 series motherboards. AMD has acknowledged these issues in a recent Reddit post where they have asked affected users for more information to help them resolve the issues. The issues appear to be most commonly found when using VR headsets on X570 motherboards where intermittent connectivity issues are most noticeable. Some of the affected users report that the issues are most common when using a PCIe 4.0 GPU and that switching to PCIe 3.0 can sometimes resolve the issue. AMD is asking affected users to submit reports through their Online Service Request platform and will also contact users directly on Reddit to request detailed information.

Update Mar 9th:

AMD has provided some official guidance for affected users asking them to follow the solutions provided by Reddit such as disabling global C-States and switching to PCIe 3.0 mode if general troubleshooting has failed. AMD has reaffirmed that they were aware of the issue and that their engineers are actively working on a fix.