I've been running 10.12 since release and it seems that yes, overclocking is broken for those with multiple monitors/eyefinity and something is broken in the drivers. I've had a BSOD per day since switching to 10.12.
It looks like they finally fixed the cursor bug, (at least I haven't had it pop up yet) and a dozen other little annoyances appear to have been fixed.
Congrats to AMD, it only took them a year to produce stable drivers.
I think it's relevant because most of the anti-Nvidia memes during the last year originated from Semiaccurate the majority of which ended up being either false or fabricated yet managed to stick.
It's hard to imagine that the Fermi/Evergreen reviews would have been the same if Charlie hadn't...