From Tweakguides.com -
ATI Catalyst Tweak Guide.
Profiles
If you want to use different graphics card settings in different circumstances, the profiles option might come in very handy. Click the Profiles button and select 'Profiles Manager' to bring up the Profiles Manager. You can save all your current Control Center settings under as many profiles as you like by entering a profile name in the box under 'Enter or select a profile name', and then click the Save button. However you can choose which particular settings are saved in the profile, and how they can be applied.
Composition: Under this tab you can select the particular Control Center settings to save for the current profile. If you click the small 'All Catalyst Control Center Settings' button all possible Control Center settings will be saved for the current profile. If you want to ignore certain settings, such as VPU Recover or Video Overlay settings for the current profile, click on the 'the following settings' button, and then you can double-click on the name of your graphics card (if you have only one display, select the first entry) and underneath it you can tick/untick the specific setting areas to add/remove.
Activation: Under this tab you can set the methods by which the profile can be activated (i.e the settings in the profile will be put into effect). There are four possible ways in which a profile can be activated:
System Tray Menu - If you use the ATI Catalyst Control Center System Tray tool then if this option is ticked you can use it to quickly access and activate your profiles.
Hotkey Assignments - If you use the ATI Hotkeys function of the Control Center, then you tick this option to assign hotkeys to activate a profile. You must then select a Hotkey Modifier key, and enter a particular key in the 'Enter a Hotkeys selection' box. This is the key combination which will activate this profile.
Profiles Menu - This item should usually be ticked, as it allows you to access profiles and activate them using the drop-down menu next to the Profiles button in the ATI Control Center. Your profiles will be listed by name under the 'Activate Profile' item of the Profiles drop-down menu.
Desktop Shortcut - This is a very useful way of activating profiles, particularly profiles which apply to particular games or applications. If this option is ticked, when you save a profile this places a special ATI shortcut on your Windows Desktop, which when launched will activate the particular profile associated with it. See the Application tab description below for more details of how to use this feature to create and use different profiles for each game.
Applications: Under this tab you can associate a particular application or game with the profile. You can do this by putting a tick in the 'opens the following application, file or shortcut' box, and then inserting the full path and name of a executable or shortcut using the Browse button. I recommend you select the path to a shortcut, as the Control Center has some issues with launching certain executables properly (e.g Doom3.exe). Unfortunately this method doesn't mean that whenever you run that application or shortcut that the drivers will automatically detect this and run the appropriate profile. That would be extremely useful, but that's not what this does. The closest you can get to that sort of ease-of-use is to tick the 'Desktop Shortcut' option under the Activation tab, then save your profile. You will now find a shortcut on your desktop which, when launched, will start the application or game you've assigned to the profile, and implement all the profile's settings.
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This is the method I suggested earlier.)
One last thing I can recommend in regards to profiles is that you should ideally save your regular "everyday" Control Center settings under a profile with a name like Default or Normal. That way you won't lose them. For more useful game profiles which are automatically detected and used when a game is launched, use ATI Tray Tools instead - see the Advanced Tweaking section for details.