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Motherboard has four M.2 sockets. Three are Gen4 X4 and one is Gen5 X4 ( which will work as Gen4 as well). These will not take away any PCIe slots.How many, and of what PCIE generation, can I add, without taking anything away from the PCIE5 slots - wanting to run x8, x8, x4. I can have one NVME? Of any gen?
The MSI xpander card will had two more M.2 sockets that support Gen5. It goes into the second PCIe slots for both to be active. However you can put it in the bottom PCIe X4 slot for just one drive.
You have 4 M.2 that doesn't effect any PCIe slots and another 1/2 that will use A PCIe slots. Leaving you with 5 or 6 depending on configuration. 8x/USED/X4 or 8x/8x/USED.
Make sense?