[Nature] Stem cells reverse woman’s type 1 diabetes — a first in the world of science & technology

[Space Lynx]

I was waiting for someone to correct that


Unfortunately there is no one size fits all with diabetes. Fasting alone can be very dangerous. If a diabetics A1C is low, eating a high carb/high sugar food is required. If it's too high, taking a shot of insulin and fasting is required.

There are specific guidelines to remain safe of course. The safest way to manage it successfully long-term is to monitor your A1C (blood glucose level) diligently and regularly, eat healthy-according to the plan set forth by your health professional, take your meds and try your best to live an active, healthy life style. Not many people are familiar with this complication but even if after following all of the guidelines set forth by your doctor or health professional. A type 1 diabetic can still get extremely sick or die from a complication called diabetic ketoacidosis (DKA)

https://www.cedars-sinai.org/health-library/diseases-and-conditions/d/diabetic-ketoacidosis.html

(I encourage anyone unfamiliar to read the above).
and it only takes a simple mistake.

People commonly (not saying you are one sC) mistake diabetes as this fluff disease that only affects the overweight, taking toes and occasionally a foot. That's a fallacy that has to stop. Diabetes the disease kills. It does not discriminate.

If a 9 year old, otherwise healthy and athletic little boy can get type 1 diabetes. Anyone can get it.

Something in the DNA gets damaged generationally for some of us too, at least I think so, I don't know if there is evidence to back it up, I know my Dad's side of the family, almost all of them have diabetes issues, starting with my grandma, all the way down to all 8 of her kids, and my infinite amount of cousins. and yes the infinite part is a joke, lol but I do have a lot of cousins. one which which did get diagnosed with type 1 at age 8, she is the only one in the family with type 1 though (rest are type 2), so I have no idea how it happens, she was healthy as could be until the day she had to go to ER and that's when they figured it all out

 

[the54thvoid]

Keep the comments to the actual science folks, and don't bring in domestic politics or opinions on pharma/regulation (that's for the conversations down the pub or the shooting range). The point of these discussions in the science forum is to talk about the science.

For a start - this is about Type I diabetes (an auto-immune disorder). It's where the pancreas doesn't produce enough insulin. As much as diet can help manage it - it's not a cure.

 

[R-T-B]

I was watching a lot of native tribe videos recently and noticed something. No sugar diet, lots of exercise every day, they were in good health, and managed not to die from infections from multiple body piercing's.

They also have incredibly high infant mortality in nearly all cases, but you know, details.

 

[KrazyT]

that special soap that can prevent skin cancer, it does no harm and does a good job, but they don't want the public to have it because it will cut into margins of skin cancer medications, etc.

Ok, it's not the subject here, but you now have to tell more about a soap than can prevent skin cancer !

 

[the54thvoid]

@KrazyT - check link in your post

 

[lilhasselhoffer]

Another good point, you are 100% right this saves loads in long term medical costs and frees up some of the supply chain (and makes it harder to get needles by bad actors), I think if this does get FDA approved someday, it will be such big news celebrities will rally behind it, companies will have no choice but to be reasonable on this one. No CEO is going to have the balls to tell someone they can't cure their Type 1 if a cure is there, so it will be interesting to see how it plays out. I still think the FDA will just make it "drug shortage status" and then pharmacies and specialty companies will be able to offer it, non-profits will get involved with celebrities, etc - there will be no stopping making it affordable, not something this big.

indeed. But all forms can be reversed.
type 3 is Alzheimers they just realized.

Low carb/keto diets reverse all these problems but they wont tell us these things.

we eat too much sugar basically its the cause and the fuel for almost all illnesses

What?

Type 1 diabetes is an auto-immune condition where because the insulin producing cells in the pancreas are attacked, the body does not produce enough insulin on its own. Type two is acquired, and may come from either insulin tolerance or a lack of production.

The article shows that regenerating insulin producing cells from stem cells, and allowing those that the immune response destroyed, is a viable solution (at least short term). Which is great. The problem is that we have way more individuals who have acquired, or type 2 diabetes. This treatment isn't for most people (in ages 30-44 we are talking .59% versus 11.03% CDC data). As such this is not a magically great solution. It's for the about 1 in 200 people who report having type 1 diabetes that cannot be managed any other way. It has yet to be proven for the 22 in 200 people in a single age bracket...which makes this a little less magic.


I...Cannot tell if you guys don't understand the science, or don't understand the numbers. Either way it's hard to e enthusiastic about a single point of data when there will have to be plenty of studies before any of this gets off the ground...let alone before we know how much it'll cost. It's a lot like buying into the Tesla hype...then watching where electric vehicles from China are right now (barring their imminent combustion of course).

 

[Count von Schwalbe]

I would be cautious of any wonder treatment coming out of the China market, and of any stem cell treatment in general. I don't want to descend into geopolitics but the scientific community has a massive issue right now with overblown or even falsified claims, and journals all too willing to publish any paper they can get ahold of even without peer review.

This is not specific to China, a lot of it is happening in the US, but the issue in China is exacerbated by the way their research facilities are run. Essentially promotion depends on getting papers published, so there is a lot of motivation to publish even entirely false papers.

https://www.science.org/content/blog-post/pressure-top

This is not to denigrate Chinese researchers in general, there is a lot of really good research coming out of those facilities. The trouble is, there is a hell of a lot more lies and fraud coming out, as it is a lot easier and quicker to do than good research. Again, this is not a China issue, just that they are probably the worst offender in general. Reading the blog linked above has a lot of high-profile case studies of faked data in the USA and Europe.

---

Now, before I sound too cynical or pessimistic, I would say I truly hope this is a real breakthrough, and becomes accessible to anyone with diabetes. I would just wait to see more papers reinforcing the results before I got on any hype trains.

 

[remixedcat]

Something in the DNA gets damaged generationally for some of us too, at least I think so, I don't know if there is evidence to back it up, I know my Dad's side of the family, almost all of them have diabetes issues, starting with my grandma, all the way down to all 8 of her kids, and my infinite amount of cousins. and yes the infinite part is a joke, lol but I do have a lot of cousins. one which which did get diagnosed with type 1 at age 8, she is the only one in the family with type 1 though (rest are type 2), so I have no idea how it happens, she was healthy as could be until the day she had to go to ER and that's when they figured it all out

there was a study done on people exposed to stuff during ww2 and 2 gens later people get genetic defects from it... Gramma was a holocaust survivor and got exposed to all kinda bad stuff and I got a lot of genetic issues and had type 2 diabetes. me n my sibs got a lot of various body problems and genetic issues

 

[Frick]

Just imagine the amount of money, the State can save on a procedure like this. Compared to giving a lifetime of subsidies for medicine like ozempic.
I think it will be well worth it, even if the cost is very high.

There are so many things that are well worth it but no one is doing.

You honestly think a pharmaceutical company would sit on the single most profitable break through in the last 20 or more years (since Viagra I'm guessing)? That's not how this works. They're sinking millions into the research, you can bet your bottom dollar they will be expecting a profit ASAP. The moment the EPA gives them the thumbs up this goes into national then very quickly worldwide production or vice versa which ever is approved first.

It mentioned a complicated procudere.

indeed. But all forms can be reversed.
type 3 is Alzheimers they just realized.

Low carb/keto diets reverse all these problems but they wont tell us these things.

we eat too much sugar basically its the cause and the fuel for almost all illnesses

Beer doesn't count!