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Here is the link to this paper fresh off the press
Some key points I will summarize here:
1. Pharyngeal virus shedding was very high during the first week of symptoms (peak at 7.11 × 108 RNA copies per throat swab, day 4)
Take away: CoVID19 is great at early transmission during asymptomatic stage.
2. Infectious virus was readily isolated from throat- and lung-derived samples, but not from stool samples, in spite of high virus RNA concentration.
Take away: CoVID19 seems to be able to invade both digestive tract cells as well as respiratory tract cells. However the ones in the gut get killed and not infectious.
3. Blood and urine never yielded virus.
Take away: good to know
4. Shedding of viral RNA from sputum outlasted the end of symptoms
Take away: Even after clear of symptoms, the now recovered paitients can still infect others.
5. . Seroconversion occurred after 7 days in 50% of patients (14 days in all), but was not followed by a rapid decline in viral load.
Take away: Human body unable to rapidly eliminate viral load follow massive antibody production and ramped up immune response. Nasty virus
6. More efficient transmission of SARS-CoV-2 than SARS-CoV through active pharyngeal viral shedding at a time when symptoms are still mild and typical of upper respiratory tract infection. Later in the disease, COVID-19 then resembles SARS in terms of replication in the lower respiratory tract.
Take away: This virus is definitely more successful than SARS using human for transmission. Very well adapted to human.
This figure shows 17 days post onset, the patient's serum produced larger quantity of immuno-protein that targers CoVID viral protein parts. Brighter image means more immunoflurocence.
Some key points I will summarize here:
1. Pharyngeal virus shedding was very high during the first week of symptoms (peak at 7.11 × 108 RNA copies per throat swab, day 4)
Take away: CoVID19 is great at early transmission during asymptomatic stage.
2. Infectious virus was readily isolated from throat- and lung-derived samples, but not from stool samples, in spite of high virus RNA concentration.
Take away: CoVID19 seems to be able to invade both digestive tract cells as well as respiratory tract cells. However the ones in the gut get killed and not infectious.
3. Blood and urine never yielded virus.
Take away: good to know
4. Shedding of viral RNA from sputum outlasted the end of symptoms
Take away: Even after clear of symptoms, the now recovered paitients can still infect others.
5. . Seroconversion occurred after 7 days in 50% of patients (14 days in all), but was not followed by a rapid decline in viral load.
Take away: Human body unable to rapidly eliminate viral load follow massive antibody production and ramped up immune response. Nasty virus
6. More efficient transmission of SARS-CoV-2 than SARS-CoV through active pharyngeal viral shedding at a time when symptoms are still mild and typical of upper respiratory tract infection. Later in the disease, COVID-19 then resembles SARS in terms of replication in the lower respiratory tract.
Take away: This virus is definitely more successful than SARS using human for transmission. Very well adapted to human.
This figure shows 17 days post onset, the patient's serum produced larger quantity of immuno-protein that targers CoVID viral protein parts. Brighter image means more immunoflurocence.
