Last night I started playing, got about 2 or 3 hours into the storyline so far. Its running okay for me, I had to update graphics drivers and have only had one crash so far when exiting the settings menu. Actually the biggest nuisance for me was the amount of bandwidth Rockstar Games Launcher pulls, it seemed to overheat my two wifi cards, even when selecting the download throttle setting in the RGL menu, and hung my wireless internet, I had to run a long ethernet cord to get things updated.
One grip I have is I find the keyboard and mouse character movement really cumbersome compared to GTA V, something about how the player walks. The graphics are phenomenal and I like the characters and storyline.
Another gripe is the save spots are a bit sparse early on.
Lastly, the settings menus are not as nicely laid out as GTA V.
Selecting Windows Mouse gave me the best mouse performance, better than Raw Input.
Interestingly the game engine seems to both run better and look better than GTA V.