• Welcome to TechPowerUp Forums, Guest! Please check out our forum guidelines for info related to our community.

Sequencing DNA Anywhere, by Anyone

Joined
Mar 18, 2008
Messages
4,282 (1.04/day)
System Name Virtual Reality / Bioinformatics
Processor Undead CPU
Motherboard Undead TUF X99
Cooling Noctua NH-D15
Memory GSkill 128GB DDR4-3000
Video Card(s) EVGA 2080Ti
Storage Samsung 960 Pro 1TB + 860 EVO 2TB + WD Black 5TB
Display(s) Acer K272HUL, HTC Vive
Case Fractal Design R5
Audio Device(s) BOSE 2.0
Power Supply Seasonic 850watt
Mouse Logitech Master MX
Keyboard Corsair K70 Cherry MX Blue
Software Windows 10 Professional/Linux Mint
Step aside 23andme and evil Google. The future of DNA sequencing and DNA security is saved by Oxford Nanopore.


Basically this new tech applications allows anyone outside of molecular genetics lab to gather tissue samples and sequence the DNA themselves without the need to use expensive lab equipment. This is some pretty amazing engineering going. Just a tube, you put your tissue sample in, can be saliva, blood or even chunks of your flesh! Then you just shake it up for some time and go on to sequencing. Everything is done locally. The DNA can be briefly interpreted using built in databases. Or it can be given to a friendly molecular genetics you trust (TPU cat like me) to do detail analysis. How cool is that?!

This opens up so many new doors. And best of all you get to keep the original copy of your DNA data, not some evil tech giant like Google.

2018.05.30-11.47.png




 
Joined
Sep 7, 2017
Messages
3,063 (4.73/day)
System Name Blackbox
Processor Intel i7-7820x
Motherboard Supermicro C9X299-PG300
Cooling Corsair H100i
Memory 16GB 2666..tentatively
Video Card(s) Powercolor Vega 64
Storage Intel 900p 280GB, 545s 512GB, Barracuda 10TB
Display(s) Viewsonic VX2457, Samsung 4KTV
Case Corsair C70
Power Supply Corsair AX860i
Software Win 10 Pro
What doors does it open? Honest question. I'm a little obsessed with crime stories, so I know the doors opened with that. But what else?
 
Joined
Mar 18, 2008
Messages
4,282 (1.04/day)
System Name Virtual Reality / Bioinformatics
Processor Undead CPU
Motherboard Undead TUF X99
Cooling Noctua NH-D15
Memory GSkill 128GB DDR4-3000
Video Card(s) EVGA 2080Ti
Storage Samsung 960 Pro 1TB + 860 EVO 2TB + WD Black 5TB
Display(s) Acer K272HUL, HTC Vive
Case Fractal Design R5
Audio Device(s) BOSE 2.0
Power Supply Seasonic 850watt
Mouse Logitech Master MX
Keyboard Corsair K70 Cherry MX Blue
Software Windows 10 Professional/Linux Mint
What doors does it open? Honest question. I'm a little obsessed with crime stories, so I know the doors opened with that. But what else?

For your human RNA. It can tell your immediate state by looking at the RNA being made in real time. A lot more in detail than regular physical check

For your human DNA, it can tell your predicted life span, immune system strength, specific gene's mutation rate.

For the bacteria living inside/outside of you. It can tell whether you have any dormant virus or disease that are inside your body but asymptomatic.

Ultimately combining this with DNA editing you can modify your own genome.


For millions of years our improvement has only been on the tools we use. Our genome and physical body remained relatively unchanged. These new DNA technology would enable a near future where human can intentionally enhance ourselves through genome reprogramming.
 
Joined
Aug 20, 2007
Messages
11,192 (2.59/day)
System Name Pioneer
Processor Intel i9 9900k
Motherboard ASRock Z390 Taichi
Cooling Noctua NH-D15 + A whole lotta Sunon and Corsair Maglev blower fans...
Memory G.SKILL TridentZ Series 32GB (4 x 8GB) DDR4-3200 @ DDR4-3400 14-14-14-34-2T
Video Card(s) EVGA GTX 1080 FTW2
Storage HGST UltraStar 7K6000 3.5" HDD 2TB 7200 RPM (w/128MBs of Cache)
Display(s) LG 32GK850G-B 1440p 32" AMVA Panel G-Sync 144hz Display
Case Thermaltake Core X31
Audio Device(s) Onboard Toslink to Schiit Modi Multibit to Asgard 2 Amp to AKG K7XX Ruby Red Massdrop Headphones
Power Supply Seasonic PRIME 750W 80Plus Titanium
Mouse ROCCAT Kone EMP
Keyboard WASD CODE 104-Key w/ Cherry MX Green Keyswitches, Doubleshot Vortex PBT White Transluscent Keycaps
Software Windows 10 x64

hat

Enthusiast
Joined
Nov 20, 2006
Messages
20,597 (4.49/day)
Location
Ohio
System Name Starlifter :: Dragonfly
Processor i7 2600k 4.4GHz :: Athlon II x4 630 3.5GHz
Motherboard ASUS P8P67 Pro :: GIgabyte GA-770T-USB3
Cooling Corsair H70 :: Thermaltake Big Typhoon
Memory 2x4GB DDR3 1866 :: 2x1GB DDR3 1333
Video Card(s) 2x PNY GTX1070 :: none
Storage Plextor M5s 128GB, WDC Black 500GB :: Mushkin Enhanced 60GB SSD, WD RE3 1TB
Display(s) Acer P216HL HDMI :: None
Case Antec SOHO 1030B :: Old White Full Tower
Audio Device(s) Onboard - iLive IT153B Soundbar (optical) :: None
Power Supply EVGA 500w 80 Plus :: Wounded Corsair CX600
Software Windows 10 Pro - Plex Server on Dragonfly
Benchmark Scores >9000
We can overclock people now? Seems like there's a few ways that could go wrong...
 
Joined
Aug 20, 2007
Messages
11,192 (2.59/day)
System Name Pioneer
Processor Intel i9 9900k
Motherboard ASRock Z390 Taichi
Cooling Noctua NH-D15 + A whole lotta Sunon and Corsair Maglev blower fans...
Memory G.SKILL TridentZ Series 32GB (4 x 8GB) DDR4-3200 @ DDR4-3400 14-14-14-34-2T
Video Card(s) EVGA GTX 1080 FTW2
Storage HGST UltraStar 7K6000 3.5" HDD 2TB 7200 RPM (w/128MBs of Cache)
Display(s) LG 32GK850G-B 1440p 32" AMVA Panel G-Sync 144hz Display
Case Thermaltake Core X31
Audio Device(s) Onboard Toslink to Schiit Modi Multibit to Asgard 2 Amp to AKG K7XX Ruby Red Massdrop Headphones
Power Supply Seasonic PRIME 750W 80Plus Titanium
Mouse ROCCAT Kone EMP
Keyboard WASD CODE 104-Key w/ Cherry MX Green Keyswitches, Doubleshot Vortex PBT White Transluscent Keycaps
Software Windows 10 x64
We can overclock people now? Seems like there's a few ways that could go wrong...
Adderall / Amphetamines /Meth and similar drugs has enabled that for a while. And yeah, pretty much.
 
Joined
Mar 18, 2008
Messages
4,282 (1.04/day)
System Name Virtual Reality / Bioinformatics
Processor Undead CPU
Motherboard Undead TUF X99
Cooling Noctua NH-D15
Memory GSkill 128GB DDR4-3000
Video Card(s) EVGA 2080Ti
Storage Samsung 960 Pro 1TB + 860 EVO 2TB + WD Black 5TB
Display(s) Acer K272HUL, HTC Vive
Case Fractal Design R5
Audio Device(s) BOSE 2.0
Power Supply Seasonic 850watt
Mouse Logitech Master MX
Keyboard Corsair K70 Cherry MX Blue
Software Windows 10 Professional/Linux Mint
Joined
Aug 20, 2007
Messages
11,192 (2.59/day)
System Name Pioneer
Processor Intel i9 9900k
Motherboard ASRock Z390 Taichi
Cooling Noctua NH-D15 + A whole lotta Sunon and Corsair Maglev blower fans...
Memory G.SKILL TridentZ Series 32GB (4 x 8GB) DDR4-3200 @ DDR4-3400 14-14-14-34-2T
Video Card(s) EVGA GTX 1080 FTW2
Storage HGST UltraStar 7K6000 3.5" HDD 2TB 7200 RPM (w/128MBs of Cache)
Display(s) LG 32GK850G-B 1440p 32" AMVA Panel G-Sync 144hz Display
Case Thermaltake Core X31
Audio Device(s) Onboard Toslink to Schiit Modi Multibit to Asgard 2 Amp to AKG K7XX Ruby Red Massdrop Headphones
Power Supply Seasonic PRIME 750W 80Plus Titanium
Mouse ROCCAT Kone EMP
Keyboard WASD CODE 104-Key w/ Cherry MX Green Keyswitches, Doubleshot Vortex PBT White Transluscent Keycaps
Software Windows 10 x64
Why not? However you need to specify which part of your body would like frog DNA infusion.
Nope. They put Frog DNA in chicken eggs with a dino blood infusion in Jurassic Park and got DINOSAURS. You can't tell me if we used frog eggs instead of chicken (along with some of my frog slime) we wouldn't get giant badass frogmen.

I would like two-thousand specimens, 50% sex distribution please, and an equal supply of AK-47s along with multilingual picture based soviet era instruction manuals. Please add my face to the forehead of each individual so they know who to worship.

Your payment will arrive after the revolution in the form of a hidden bog bunker with all the science supplies the frog men did not eat, defecate, or lay eggs in.

Don't tell me this won't work. Micheal Criton and Steven Spielberg know the truth.
 
Joined
Oct 22, 2014
Messages
7,165 (4.22/day)
Location
Sunshine Coast
System Name Black Box
Processor Intel Xeon E5-2680 10c/20t 2.8GHz @ 3.0GHz
Motherboard Asrock X79 Extreme 11
Cooling Coolermaster 240 RGB A.I.O.
Memory G. Skill 16Gb (4x4Gb) 2133Mhz
Video Card(s) Nvidia GTX 710
Storage Sandisk X 400 256Gb
Display(s) AOC 22" Freesync 1m.s. 75Hz
Case Corsair 450D High Air Flow.
Audio Device(s) No need.
Power Supply FSP Aurum 650W
Mouse Yes
Keyboard Of course
Software W10 Home Premium 64 bit
Don't tell me this won't work. Micheal Criton and Steven Spielberg know the truth.
Steven Kings version would be more fun.

This opens up so many new doors. And best of all you get to keep the original copy of your DNA data, not some evil tech giant like Google.
I believe some time in the 1970's all Hospitals started keeping DNA samples and records, so Google isn't the only one that collects data.
 
Joined
Aug 20, 2007
Messages
11,192 (2.59/day)
System Name Pioneer
Processor Intel i9 9900k
Motherboard ASRock Z390 Taichi
Cooling Noctua NH-D15 + A whole lotta Sunon and Corsair Maglev blower fans...
Memory G.SKILL TridentZ Series 32GB (4 x 8GB) DDR4-3200 @ DDR4-3400 14-14-14-34-2T
Video Card(s) EVGA GTX 1080 FTW2
Storage HGST UltraStar 7K6000 3.5" HDD 2TB 7200 RPM (w/128MBs of Cache)
Display(s) LG 32GK850G-B 1440p 32" AMVA Panel G-Sync 144hz Display
Case Thermaltake Core X31
Audio Device(s) Onboard Toslink to Schiit Modi Multibit to Asgard 2 Amp to AKG K7XX Ruby Red Massdrop Headphones
Power Supply Seasonic PRIME 750W 80Plus Titanium
Mouse ROCCAT Kone EMP
Keyboard WASD CODE 104-Key w/ Cherry MX Green Keyswitches, Doubleshot Vortex PBT White Transluscent Keycaps
Software Windows 10 x64
Joined
Apr 12, 2013
Messages
2,496 (1.11/day)
Slightly (or massively) off topic but has anyone tried to replenish/regenerate telomeres or telomerase in humans?
 
Joined
Aug 20, 2007
Messages
11,192 (2.59/day)
System Name Pioneer
Processor Intel i9 9900k
Motherboard ASRock Z390 Taichi
Cooling Noctua NH-D15 + A whole lotta Sunon and Corsair Maglev blower fans...
Memory G.SKILL TridentZ Series 32GB (4 x 8GB) DDR4-3200 @ DDR4-3400 14-14-14-34-2T
Video Card(s) EVGA GTX 1080 FTW2
Storage HGST UltraStar 7K6000 3.5" HDD 2TB 7200 RPM (w/128MBs of Cache)
Display(s) LG 32GK850G-B 1440p 32" AMVA Panel G-Sync 144hz Display
Case Thermaltake Core X31
Audio Device(s) Onboard Toslink to Schiit Modi Multibit to Asgard 2 Amp to AKG K7XX Ruby Red Massdrop Headphones
Power Supply Seasonic PRIME 750W 80Plus Titanium
Mouse ROCCAT Kone EMP
Keyboard WASD CODE 104-Key w/ Cherry MX Green Keyswitches, Doubleshot Vortex PBT White Transluscent Keycaps
Software Windows 10 x64
Slightly (or massively) off topic but has anyone tried to replenish/regenerate telomeres or telomerase in humans?
Fountain of youth you think?
 

Norton

Moderator & WCG-TPU Captain
Staff member
Joined
Dec 21, 2011
Messages
13,805 (5.05/day)
Location
USA
System Name My Fortress/Julia (WCG)/Trish (WCG)/Ella (WCG)/Junior (WCG)/4P (WCG)/Kreij (WCG)/Trish02 (WCG)
Processor Ryzen 1700X/Ryzen 1700X/Ryzen 1700/Ryzen 1600X/Ryzen 1800X/Opteron 6168x4/FX-8350/Ryzen 1800X
Motherboard X370 Taichi/A320 Pro-VHL/B350 M/B350 M/AB350 K4/SuperMicro 4P/ASUS 990X/ Asrock X370 mITX
Cooling NH-D14/SNH-U14S/Scythe Mugen5/Scythe Mugen 5/NH-U14S/CM 212+ (x4)/Xig DK Nighthawk/Scythe Mugen 5
Memory 16GB GSkill TridentZ-3200 (1700X), 16GB GSkill FlareX-2400 (1800X),... various...., 4P- 16x1GB
Video Card(s) RX 580/HD 7770/HD 4670/GTX 1080/8400GS/onboard/GTX 1080/HD 7870
Storage WD 500GB SSD/Seagate 2TB SSHD, .... misc...
Display(s) Dual Dell Ultrasharp U2414H
Case Silverstone FT01B/Corsair 230T/Versa H15/Silverstone FT05/Define R4/custom/Tt P3 open/Define XL r2
Audio Device(s) on board (All)
Power Supply Corsair HX850/CS650M/Focus Gold 650/EVGA P2 850/HX 650/X Gold 1050/M12 II 750/X Gold 750
Mouse Logitech G300s
Keyboard Thermaltake Challenger Prime (Great for $30!!!)
Software Win 10 Pro (Fortress), Win 10 Pro (Ella02), Ubuntu for everything else
Benchmark Scores Why sit on the Bench when you can get in the game and Crunch!!!
@xkm1948 please keep this thread on topic so it can remain open and active in the S&T section of the forum.

Members are reminded that this is a S&T thread not a Lounge thread so while a little light OT discussion is tolerable, stick to the science 1st
 
Joined
Mar 18, 2008
Messages
4,282 (1.04/day)
System Name Virtual Reality / Bioinformatics
Processor Undead CPU
Motherboard Undead TUF X99
Cooling Noctua NH-D15
Memory GSkill 128GB DDR4-3000
Video Card(s) EVGA 2080Ti
Storage Samsung 960 Pro 1TB + 860 EVO 2TB + WD Black 5TB
Display(s) Acer K272HUL, HTC Vive
Case Fractal Design R5
Audio Device(s) BOSE 2.0
Power Supply Seasonic 850watt
Mouse Logitech Master MX
Keyboard Corsair K70 Cherry MX Blue
Software Windows 10 Professional/Linux Mint
Slightly (or massively) off topic but has anyone tried to replenish/regenerate telomeres or telomerase in humans?

Our human genome regulation operate differently from small mammmals like rodents. And yes, rodents constantly regenrate their telemeres throughout its life.


You wanna take a guess what cells in adult human would do the same thing?

cancer cells

It is always hard to balance genome regulation versus tumorgenesis. Most long lived mammals tend to tightly regulate the regeneration of telemers to control growth of tumor.


The best bet for pro-longing healthy human life span is through targeted epigenome modulation. Either CRISPR guided DNA methylation editing or synthetic RNA injection.
 
Joined
Apr 12, 2013
Messages
2,496 (1.11/day)
Fountain of youth you think?
What gave it away :D
Our human genome regulation operate differently from small mammmals like rodents. And yes, rodents constantly regenrate their telemeres throughout its life.


You wanna take a guess what cells in adult human would do the same thing?

cancer cells

It is always hard to balance genome regulation versus tumorgenesis. Most long lived mammals tend to tightly regulate the regeneration of telemers to control growth of tumor.


The best bet for pro-longing healthy human life span is through targeted epigenome modulation. Either CRISPR guided DNA methylation editing or synthetic RNA injection.
I remember reading somewhere that a certain species of birds(?) IIRC constantly regenerates telomeres, & yes I know that telomere regen has different effects for different organisms. I'm just fascinated by much of this, if I hadn't picked up CS after high school then biology was my favorite subject. I've followed Discovery & NG constantly for better part of 2 decades.

Thanks you for bringing more info from your own work here.

Norton you can remove the last few posts if they're an unneeded distraction. I'd however request you to move them to another thread, if possible.
 
Joined
Mar 18, 2008
Messages
4,282 (1.04/day)
System Name Virtual Reality / Bioinformatics
Processor Undead CPU
Motherboard Undead TUF X99
Cooling Noctua NH-D15
Memory GSkill 128GB DDR4-3000
Video Card(s) EVGA 2080Ti
Storage Samsung 960 Pro 1TB + 860 EVO 2TB + WD Black 5TB
Display(s) Acer K272HUL, HTC Vive
Case Fractal Design R5
Audio Device(s) BOSE 2.0
Power Supply Seasonic 850watt
Mouse Logitech Master MX
Keyboard Corsair K70 Cherry MX Blue
Software Windows 10 Professional/Linux Mint
At the heart molecular genetics and computer science is the same thing. One codes in binary, another codes in DNA. I started off as computer science during my early college years. Then I ventured into molecular genetics.

It is amazing how every single cell in your body use the same 3 Billion basepair genome, yet their physical property are so vastly different. It is seriouly some of the finest coding.
 
Top