Periodically when I wake my computer from sleep my USB devices do not work. In most cases even when they do it takes 15 seconds or so, but not always. Sometimes they begin to work if I unplug then plug them back in. My computer goes into an S3 power state for sleep. This has been the strangest board I've ever owned in regards to sleep. I cannot turn the wake from USB option on. The computer goes to sleep and immediately kicks out of it if I do. Its all completely random, and I hate to have to do a hard reset when it does occur.