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When gaming.. Pointer move Up

Jul 17, 2007
741 (0.19/day)
Processor x2 4400+
Memory 3gig
Video Card(s) 8800 gts 512mb
Power Supply 500w zumax
I was playing a game. the game has a build-in gamepad setup but I use joy2key instead.... after using joy2key it messed me up badly! it messed up the in-game build-in gamepad setup! the build-in gamepad setup no longer work for me! also my pointer auto move north non-stop! helpppp!!!! I am desperate!

what is the problem? I even reboot and reinstall the game but still no help!