I guess it all depends on what you hope to squeeze from the cards and if you plan to put them under water. I'm a big fan of the reference cards for the voltage control so if you want e-peen clock from the card I think that's your best but. If you don't plan to push for +1000Mhz and have no interest in water cooling than I'd get the toxic. Buying the Vapor-X card just to remove the cooler would be a waste IMO. I know W1zz was using a 5870 PCS+ in his personal system and appeared quite happy with it but other than that I have no experience with them.