Okay folks, I have had much of a system change since lightning took out my AMD box. My new system is in my sig and I have had it for about 4 months now I have 3 USB Enclosures. A Hornettek JAWS and a Hornettek Viper, USB 3.0 Editions. I also have a Kingwin USB 3.0 edition. When using the drives with this particular motherboard, I get some weird behavior from the Hornetteks. Randomly when the system is operating, the drives will disconnect from the system and shutdown power to themselves. To get the drives back, I have to disconnect power..... wait 10 secs.... plug them back in. I have ensured all power management is disabled. It does not matter if the drives are idle or being used. I have updated my BIOS and drivers to the latest versions. I am not overclocking anything. I contacted Hornettek and RMA'd both boxes. They sent me two new ones and the issue still occurs. The Kingwin box is fine. Does not matter if I am using USB 3.0 or 2.0 ports. Keyboard and mouse, along with all other USB devices is fine. Contacting MSI resulted in my sending my motherboard in for RMA. I really really REALLY do not want to tear out this watercooling. Any thoughts??? Suggestions?? I am ruling out my PSU... I mean 1250W.... should be plenty for 6 USB devices... I have updated the BIOS and all Drivers.