Tricks for more performance? Use Geforce Experience, but not many games are supported. Out of the 130 or so games I have installed, only about half have profiles in GF-Experience. It will do things like set the game to render at a higher res, and then automatically scale it down (there's some fancy name for this), make sure proper settings are enabled in-game for decent performance (it changes options based on your monitor's resolution and the number of GPUs you have installed), and many other things that help ensure that with supported titles your rig plays everything really well.
SLi doesn't enable for non-supported games. You never need to disable.
Otherwise, just leave it alone one you set it. Nvidia has spent many 1000's of man-hours making sure the driver is intelligent enough to do most things for you, provided you give it some primary basic feedback about your configuration.