I'm speaking about issues with at least 15 PC using various Radeon RDNA/RDNA2 .... I would say it is not my setup.
I'm doing this since last 30+ years, I think I could define myself as a quite competent IT guy.
I'm still using Radeon for some build, because value is usually better than Nvidia counterpart (see Radeon 6600/6600XT), but I'm always expecting complaints after that...
problems with AMD always are at the software level. Chipset, VGA or CPU...
Their hardware is great.
I have built over 30 Ryzen builds in the last 2 years without 1 complaint from Mining to Gaming. I can say that the 5000 series did have Gremlins but the 6000 series is rock solid. The only Software gremlin I had (other than what I mentioned) was one from January last year that sent my GPU power draw to 330 Watts (6800XT). I am pretty sure that within 2 weeks AMD provided a fix for that. The software is where for me AMD shines. The fact that I don't have to run MSI afterburner and 3DMark to test my system or get System info is great. Even the AUTO OC function in the software is rock solid. With 2 clicks I was able to set my 6500XT to 2903 MHZ on the GPU and 2400 on the Memory. I ran the stress test for 30 minutes and not one hiccup. They literally update the software every month with nice usable upgrades every now and then.
Where I can say issues come up is with the "Popular" products like:
Corsair Vengeance RAM 3600 MHZ but cannot go past 2933: Gskill all the way or Crucial even Team all worked as advertised.
Gigabyte MBs that like to die unless you know to take out the battery and re-insert it. (Sometimes)
Gigabyte GPUs that run hot or black screen until you add thermal paste to the GPU
MSI MBs that can just die on you for no apparent reason (especially lately).
The ASUS B550-F (Non WIFI) that shares lanes with all the PCIe slots (Not the 1st slot) "highly recommended on Youtube
Trying to do an RMA with Asus
People thinking the PSU should be an afterthought
People that think AMD means cheap instead of Value
People that will want the B550 Tomahawk over the X570 PRO for a 5600X build.