BTW, what you're asking *used to be* standard. Every single pre-built desktop PC I've had hands on made before the 20teens, separated the CPU's airflow from the rest of the case, in some manner.
IIRC, it was part of Intel's 'Thermally Advantaged Chassis Design' guidelines.
Ummm, I think you are confusing something with something else - though not sure what with what. There never was such a "standard". There were several, essentially futile attempts to bring cool air into the case and directly on to the CPU using side panel tubes with fans, but as I said, they proved to be futile - in part because more and more tower/side firing coolers started to appear on the market.
Plus, we soon learned that side panel fans tended to disrupt the desired front-to-back flow of cool air.
Then the use of alternative cooling solutions (water blocks and radiators) put nails in that coffin, and the concept of
Thermally Advantaged Chassis essentially died.
Pets4Ever said:
Why don't cases seperate CPU from GPU for thermal reasons?
Many reasons.
It is not just up to case designers to make that decision. The ATX Form Factor standard is managed by a consortium of manufacturers from all over the computer industry, from makers of cases, motherboards, PSUs, expansion cards, and more.
The CPU is located on motherboards of different sizes in a specific, ATX Form Factor defined place. Why? So case makers and motherboard makers know where to put additional mounting points in the same places to ensure there is enough support for heavy CPU coolers, regardless the case or motherboard.
Expansion card slots are positioned on motherboards and cases in specific, ATX defined places so inserted cards line up properly with cases, regardless the motherboard or the case.
And of course, there is the whole rear panel I/O connection section, specifically located in a defined location on every ATX compliant motherboard so that it will align properly with the rear panel I/O area of the case.
The ATX Form Factor standard was created for us consumers (and so 3rd party HW makers could compete with IBM). It is what allows us to avoid proprietary solutions and instead, we can choose to put an ASUS AMD motherboard in an FD case with a Gigabyte graphics card and Samsung RAM and drives, and Seasonic PSU. Then tomorrow, swap all that out and put in a MSI Intel motherboard with EVGA graphics, WD drives, Kingston RAM and a Be Quiet! PSU and have confidence they all will properly fit physically, with compatible connectors and voltages, and run just fine. And then the next day, swap everything into a Coolermaster case.
Even things like PSU mounting screws (size, thread count, etc.) are controlled by the ATX standard. And that is a very good thing for us consumers.
Without such a standard, the build-it-yourself PC industry would essentially be non-existent - just as the build-it-yourself laptop industry is. Everything would be proprietary, more expensive to buy, more expensive to repair, and upgrade options (if any) would be very limited and more expensive too.
The adherence to the ATX standard are looser and looser.
Kinda, sorta, but not really. There are exceptions, of course, but if you buy a mid-tower ATX compliant case for example, you can still mount any ATX compliant motherboard , any ATX compliant power supply, and any ATX compliant drive in there. If you can't, then it is not an ATX compliant case and as such, will likely have several proprietary features - typically not good when it comes to future upgrade options.
If you look at modular power supplies for example. The ATX Form Factor standard ensures the voltages and the component ends of the power cables are standard. But there are no such standards for the PSU end. For that reason, we cannot, without careful research, mix and match modular cables from different supplies and be certain of compatibility - often not even from the same brand!

Not good!
Manufacturers are able to design cases with isolating compartments for the PSU simply because PSUs connect to components by cables already. But there are major disadvantages to using cables to interconnect other major components.
There is a reason Intel and the other ATX members designed the standard to position the CPU, the graphics solution and RAM as close as possible to each other. That is to
decrease the distance between them in order to reduce "transport latency" across the motherboard bus.
"Transport latency" is the time it takes for a request/response to be transmitted to/from processing components. Increasing the distance between the components increases transport latency. NOT GOOD!
Riser cables, regardless how good, add distance between the CPU and GPU. They also add two additional connectors. No connector is 100% efficient (compared to a straight wire).
If not concerned with transport latency across the motherboard bus, then I would suggest sticking with integrated graphics (today's are quite good) and not worry about a graphics card, its cooling or riser cables.
I say, keep case design the way it is.
And I say, AMD and NVIDIA and the various graphics cards makers need to improve efficiency of their GPUs and cards to reduce heat generation. And they need better cooling solutions to better extract the heat out the back QUIETELY (I hate fan noise).