You mean supporting a 64 bit OS or 64 bit audio out? If 64 bit audio out, does that actually exist in mainstream?
No HDMI or SPDIF don't currently have 32 bit capability, although both can if updated.
SPDIF and HDMI both run on HDA, so if HDA cannot do 64 bit, then nor can anything attached to it.
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TOSLink certainly has the bandwidth to do 64bit, @ 125mb max, but no supporting hardware.
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You would need a replacement to HDA, that is also HDA compatible, maybe UDA, or
parallel HDA.
Here you can see Realtek (Optical) and AMD (GPU, Monitor) are HDAUDIO (HDA).
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