MSI is approaching the socket AM3+ performance platform with two motherboards based on the AMD 990FX chipset, at the very top is the 990FXA-GD80 detailed earlier. Next to it, is the 990FXA-GD65, which is designed to occupy a sub-$200 price point. The GD65 depends entirely on the chipset for its features, with very little 3rd-party features. It uses a full-fledged 10-phase VRM to power the CPU. To add electrical stability, a 6-pin PCI-E power connector is in place, if discrete graphics cards that rely on slot power, are used. The 990FX northbridge gives out two PCI-Express 2.0 x16 ports, which are wired to two PCI-Express 2.0 x16 slots that run at full-bandwidth all the time. Other expansion slots include four PCI-E x1 and a legacy PCI.

All six SATA 6 Gb/s ports from the SB950 southbridge are assigned as internal ports, while there are no eSATA ports on the rear panel, MSI might bundle an eSATA bracket that extends two of the six internal ports as eSATA. This way, MSI saved the cost of using an additional third-party SATA controller. Other connectivity includes 8-channel HD audio driven by Realtek ALC892 CODEC that supports optical and coaxial SPDIF output; and two USB 3.0 ports on the rear panel driven by an NEC/Renesas-made controller. There's little more to this board than that, for overclockers. There is a rear-panel CMOS reset button, and "Military-grade" components. Instead of using UEFI firmware with its GUI-driven setup program ClickBIOS, MSI used conventional BIOS with a hack that allows it to boot from volumes greater than 2.2 TB in size. MSI also includes BIOS Code Unlocked Technology, which lets users unlock disabled cores on certain CPUs.