See this post for Linux! The below is for Windows only. Introducing the next generation of BOINC configuration! The first generation may be found here It really is self explanatory. If you want details on something, hover over it and the tooltip will explain it. The only thing that warrants a more thorough explanation is the "exclusive applications." Note: In short: 1) drop desired cc_config.xml on BOINC Config Utility.exe, 2) click Apply, 3) ??????, 4) Profit! In long: The application should support drag and drop capability on the executable. That is, if you drop a cc_config.xml on to the executable, it should load the no_gpu, exclusive_app, exclusive_gpu_app, and report_results_immediately settings in the file on to the GUI, you can then modify it if desired, and click Apply to inject the settings into the computer's cc_config.xml and make BOINC read them immediately. It's a quick way apply the settings without hunting for cc_config.xml on each computer and making it read cc_config. Two steps and it is done. Spoiler: Exclusive Applications Long story short, if an application is in this list, BOINC will do less or no work. Specifically: Default - Is the same as not being on the list at all. BOINC will function normally even if this process is running. GPU - If this process is detected, BOINC will suspend all GPU work. It will still do CPU tasks. All - If this process is detected, BOINC will suspend all tasks (GPU & CPU). Use this on processes where BOINC interferes. Spoiler: Version History 1.0.4 - Added no_priority_change, start_delay, and path to cc_config.xml. 1.0.3 - Many usability improvements. 1.0.2 - Added support for Server 2003 (maybe XP too) and BOINC client 5.10. 1.0.1 - Changed "Program" to "Running;" redid the running dialog so now it shows process ID, process name, and CPU usage; made the exclusive app and running list views sortable via clicking on the column header; and made it save exclusive GPU apps even if no GPUs is set to true. 1.0.0 - Initial release.