Literally no different than if you had an Intel/Nvidia.I use a dedicated DAC for my audio so I don't need any drivers, I will just let Win 10 auto install that one.
AMD Chipset B450 direct from AMD
Navi Driver direct from AMD
LAN from mobo site
that's it? I don't worry about RGB stuff or anything like that, and I don't use "utilities" stuff. I prefer vanilla