My CPU and GPUs are watercooled but not overclocked. I don't really see the need to push their performance to the limit when everything I do runs fine. However, with watercooling they are cool and quiet. It depends on how you want to run the loop. Look at my TJ07 build log (link in sig) to see a couple different ways of doing this. Right now I have a 45-degree fitting coming off the CPU down to the video cards.