It appears that players are having problems after reinstalling BioShock a few times. BioShock is using Sony's anti-piracy SecuROM which contacts them with your hardware specifications. SecuROM's website states "Only legitimate customers who have purchased the product are able to unlock the program which is bound to the hardware after activation. This ensures that once activated, it cannot be transferred to another PC and therefore not being mass pirated." Players are reporting after installing the game more than two times will stop the installation process. So not only is it being bounded to your current hardware. It will also lock you out after too many installs.