I didn't had that. My motherboard didn't listen me first 2-3 days, OC Issue with BSOD after any change in BIOS connected with CPU Clock or voltage, even downclock recognized in few situations in early days of X99 on different motherboards.
But I was patient and after that she become one of best mobo I ever had.
Probably bug with BIOS Chip fixed after ASUS BIOS Flashback.
10 EZ Update didn't change nothing except BIOS Number and model.
One Flashback with powered off fix everything.
Users who constantly push edges can't expect from any hardware to behave normal and do everything you set.
X99 is pretty nice platform for longer usage, despite to early DDR4 kits and optimization. I missed first bugs because I bought 5-6 months after launch.
Only reviews decide to spare enthusiasts from comparison between i7-6900K 4.3GHz vs i7-7820X 4.3GHz and i7-6950X 4.3GHz vs i9-7900X 4.3GHz...
That would be nice review for gaming and multi threaded applications and only valid comparison for user of X99.
When computer behave weird I used to first check motherboard, special if completely different weird problems happen one by one.
If you don't know what is problem you need to remove everything out and start with CPU, mobo, simple GPU and memory on default value.
First install system and check if everything is OK. Than you change one by one thing every 3-4 days. In mean time you use computer as normal, play games, look movies, etc...
OC first CPU, than memory manual, than timmings, between every change 3-4 days. If everything work than you can try XMP. Maybe something do that on different way, but I have time, I'm not impatient to system need to be pushed to the edges instantly.
I don't like to push system to the edges because for something like that I always need to have money to replace everything.
I like more to used space Intel or NVIDIA or AMD left to people OC. Every hardware is launched with some space... i7-5960X have
1000MHz free to be overclocked, Intel give you Turbo and you have few hundreds MHz over that, they planned that. But not 1500MHz even if good part of them could work like that.
Now with new generations OC is much lower because AMD surpised them and they didn't had other options than to push clock 500MHz more.
For Z chipset is not problem, for X chipset motherboards need new VRM. To be be honest and after Ivy Bridge they didn't left nothing special for Z chipset over Turbo. 300-400MHz maybe.