It depends ... I have had the systems demand a reboot ... I have had multiple installs witha problem requiring a OS install. I have even had utility softwater (back up in this instance) currpt a driver install. Onew thing you should always do, unless you opted for the cheapest possible MoBo, is skip the installation of drivers "in the box".
1. The higher up you go in proce, the MoBo often comes equipped with special drivers and programs with additional brand specifc improvements. With utility software and some multimedia stuff, the "key code" is embedded in the code on the MoBo CD. Don't use the CD, don't get the license.
2. Also best to establish an 'out of box' working condition cause if ya call TS, that's what they may ask . First think ya learn in TS training is the job is not to help the customer but to get them off the phone. So yes, I have had those, please wipe the drive and reinstall the OS with supplied drivers first discussions with Asus.
3. Finally, also have to watch ... some drivers require that certain windows updates have been installed.
4. Finally, some drivers are mutually exclusive, at least according to Asus. Have no use for wireless on desktop but when PC is being build, mo ethernet cable nearby so I used the Wifi to build ... move no office, connected ethernet and, at least accoridng to Asus, can only have one active at a time.