ASUS returned to its extremely durable TUF (The Ultimate Force) line of motherboards with the TUF X299 Mark 2. You'll notice that it dropped the "Sabertooth" moniker. This LGA2066 motherboard covers all the feature-set checkboxes of a premium motherboard plus the military-grade durability people have come to expect of the TUF series. It draws power from a combination of 24-pin ATX, 4-pin ATX, and 8-pin EPS power connectors, conditioning it using an 8-phase VRM.

The TUF X299 Mark 2 features eight DDR4 DIMM slots, three PCI-Express 3.0 x16 slots (x16/x16/NC or x16/x8/x8), an open-ended x4, and two x1 slots completing the expansion area. Storage features include two 32 Gb/s M.2 slots (of which one is perpendicular), and six SATA 6 Gb/s ports. USB connectivity includes two USB 3.1 ports (one each type-A and type-C), and eight USB 3.0. 8-channel HD audio driven by a Realtek ALC1220A CODEC, and a single gigabit Ethernet connection, powered by Intel i219-V make for the rest of it.